CD147 Receptor Is Essential for TFF3-Mediated Signaling Regulating Colorectal Cancer Progression

Via binding to CD147, TFF3 enhanced CD147-CD44s interaction, resulting in signal transducer and activator of transcription 3 activation and prostaglandin G/H synthase 2 expression, which were indispensable for TFF3-induced colorectal cancer migration, proliferation, and invasion.