STAT5

[EMBO Journal] Researchers revealed Pax5-Jak2 as an important nuclear driver of leukemogenesis by maintaining phosphorylated STAT5 levels in the nucleus.

[Circulation] Investigators utilized mouse models of reperfused myocardial infarction, angiotensin II and phenylephrine infusion, and diphtheria toxin cardiomyocyte ablation to investigate C-C chemokine ligand 17.

[Nature Communications] The authors demonstrated that lymphoid-restricted mutant IL7R, expressed at physiological levels in conditional knock-in mice, established a pre-leukemic stage in which B cell precursors displayed self-renewal ability, initiating leukemia resembling PAX5 P80R or Ph-like human B-acute lymphoblastic leukemia.

[Leukemia] Utilizing a Flt3-ITD knock-in, Dnmt3a haploinsufficient mouse model, researchers demonstrated that Gab2 was essential for the development of Flt3-ITD driven acute myeloid leukemia in vivo, asGab2 deficient mice displayed prolonged survival, presented with attenuated liver and spleen pathology and reduced blast counts.

[Biofactors] A series of experiments were performed to systematically investigate the cellular behavior of growth hormone (GH)/GH receptor (GHR) in MSCs, and the results showed that GH/GHR not only internalized into the cytoplasm, but also transported into the cell nuclei of MSCs.

[Leukemia] Researchers discovered that FMS-like Tyrosine Kinase 3 (FLT3)-internal tandem duplication (ITD) directly binded to CSF2RB in acute myeloid leukemia (AML) cell lines and blasts isolated from AML patients.