The IL-3, IL-5, and GM-CSF Common Receptor Beta Chain Mediates Oncogenic Activity of FLT3-ITD-Positive AML

Researchers discovered that FMS-like Tyrosine Kinase 3 (FLT3)-internal tandem duplication (ITD) directly binded to CSF2RB in acute myeloid leukemia (AML) cell lines and blasts isolated from AML patients.