T cells

[Nature Cancer] The authors reported the identification of tumoral ring finger protein 2 (RNF2), the core subunit of polycomb repressor complex 1, as a negative regulator of antitumor immunity in various human cancers, including breast cancer.

[Molecular Therapy] To combat SARS-CoV-2, researchers characterized a temperature-stable vaccine candidate that used a replication-competent, attenuated vaccinia virus as a vector to express a membrane-tethered spike receptor binding domain (RBD) antigen.

[Molecular Therapy-Nucleic Acids] A type of smart exosomes was developed, in which the exosome surface was functionally engineered with CD62L and OX40L by forced expression of the genes in the donor cells.

[Journal of Nanobiotechnology] Scientists developed a novel nanocomposite, polyethyleneimine-modified dendritic mesoporous silica nanoparticles loaded with microRNA-125a to synergistically enhance immune response and immunosuppression reversion, ultimately generating a tumoricidal environment.

[Cytokine] The authors investigated supportive therapy potential of acidophilus milk and propolis extract in the mouse xenograft breast cancer model.

[American Journal of Transplantation] Researchers performed full transcriptomic RNA sequencing and qPCR to evaluate the effects of mevalonate on the immunoregulatory phenotype of endothelial cells.