RNF2 Ablation Reprograms the Tumor-Immune Microenvironment and Stimulates Durable NK and CD4⁺ T Cell-Dependent Antitumor Immunity

The authors reported the identification of tumoral ring finger protein 2 (RNF2), the core subunit of polycomb repressor complex 1, as a negative regulator of antitumor immunity in various human cancers, including breast cancer.