T cells

[Scientific Reports] The authors reported a phenotypic screening of a human secretome library in human Treg cells utilising a high throughput flow cytometry technology.

[Molecular Oncology] Researchers explored the translation control of melanoma-overexpressed antigen 1 (MELOE-1) and provided evidence that heterogeneous nuclear ribonucleoprotein A1 (hnRNP-A1) bound to the MELOE-1 internal ribosomal entry sequence (IRES) and acted as an IRES trans-activating factor to promote the translation of MELOE-1 in melanoma cells.

[Blood Reviews] Scientists summarize the current knowledge about statins and other agents used as endothelial protectants. They propose further studies using statins for prophylaxis and prevention of end-organ damage related to extensive endothelial dysfunction in hematopoietic stem cell transplantation and chimeric antigen receptor-T cells.

[Bone Marrow Transplantation] The ASTCT, CIBMTR, and the EBMT, jointly convened an expert panel to formulate consensus recommendations for role, timing, and sequencing of auto-, allo-hematopoietic cell transplantation, and chimeric antigen receptor T-cell therapy for patients with newly diagnosed and relapsed/refractory mantle cell lymphoma.

[Journal of Experimental Medicine] Optically clear immunocompromised zebrafish were engrafted with fluorescent-labeled human cancers along with CAR T cells, bispecific T cell engagers, and antibody peptide epitope conjugates, allowing real-time single-cell visualization of T cell–based immunotherapies in vivo.

[Cancer Cell] Researchers compared the efficacies of sequential and/or combinatorial regimens in subcutaneous murine models of melanoma driven by BrafV600, Nras, or Nf1 mutations as well as colorectal and pancreatic carcinoma driven by KrasG12C.