T cells

[Leukemia & Lymphoma] The authors investigated the prognostic significance of T cell immunoglobulin and mucin domain-containing protein 3 (TIM-3) in t(8;21) acute myeloid leukemia (AML). A total of 47 t(8;21) AML patients were tested for TIM-3 expression by multi-parameter flow cytometry at diagnosis.

[Acta Pharmaceutica Sinica B] CAR-T cell therapy has shown more efficiency in cancer treatment, particularly regarding blood cancers. The expression of specific markers such as TAAs on CSCs in varied cancer types makes them as potent tools for CAR-T cell therapy.

[Biomedicine & Pharmacotherapy] The authors highlight the interactions between mesenchymal stem cells (MSCs) and different immune cells to mediate immunomodulatory functions along with the importance of MSCs therapy for the successful islet transplantation.

[Nature Communications] Single-cell transcriptomics and multiparametric imaging applied to a mouse model of breast cancer reveals that the aggressive tumor niche was characterized by an expanded basal-like population, specialization of tumor subpopulations, and mixed-lineage tumor cells potentially serving as a transition state between luminal and basal phenotypes.

[Journal of Clinical Investigation] Scientists mice with endothelial-specific overexpression of DEL-1 were protected from arthritis relative to WT controls, while arthritis was exacerbated in DEL-1-deficient mice.

[Cell Reports Medicine] By studying 51 different T cell receptors (TCRs), scientists showed that conventional genetic engineering by viral transduction led to variable TCR expression and functionality as a result of variable transgene copy numbers and untargeted transgene integration.