Single-Cell Evaluation Reveals Shifts in the Tumor-Immune Niches That Shape and Maintain Aggressive Lesions in the Breast

Single-cell transcriptomics and multiparametric imaging applied to a mouse model of breast cancer reveals that the aggressive tumor niche was characterized by an expanded basal-like population, specialization of tumor subpopulations, and mixed-lineage tumor cells potentially serving as a transition state between luminal and basal phenotypes.