T cells

[Cell Reports] The authors demonstrated the applicability of high-content imaging to human T and natural killer cells and develop a pipeline for unbiased analysis of high-definition morphological profiles.

[Cell Reports] Researchers showed that serine/arginine-rich splicing factor 1, which was decreased in T cells from patients with systemic lupus erythematosus, was necessary for the homeostasis and proper function of Treg cells.

[Leukemia] Scientists utilized mass cytometry and single-cell transcriptome analysis to identify several expanded populations within the angioimmunoblastic T-cell lymphoma tumor microenvironment.

[Immunity] Scientists demonstrated that precursors of exhausted T cells sustained mitochondrial fitness, including high spare respiratory capacity, while exhausted effector T cells deteriorated metabolically over time.

[Cell Reports] Mass spectrometry analysis on the supernatant of human melanoma cells revealed 12 peptides capable of priming healthy-donor CD8+ T cells that recognized and killed human melanoma cells in vitro and when xenotransplanted in vivo.

[Proceedings of the National Academy of Sciences of the United States of America] Researchers suggested that missense p53 mutations may have contributed to worse PDAC prognosis by promoting a more vigorous fibrotic tumor microenvironment and impeded the ability of the immune system to eliminate the cancer cells.