T cells

[Celyad Oncology] Celyad Oncology SA announced it has taken the decision to voluntarily pause the CYAD-101-002 Phase Ib trial due to reports of two fatalities that presented with similar pulmonary findings.

[Cell Metabolism] Researchers summarize recent advances of how metabolic circuits combined with epigenetic changes dictate T cell fate decisions and shape their functional states.

[Cell Reports Medicine] The authors used blood transcriptomics, multiparameter flow cytometry, and T cell receptor sequencing spanning the time of incident non-severe infection in unvaccinated virus-naive individuals to identify rapid type 1 interferon (IFN) responses common to other acute respiratory viruses and cell proliferation responses that discriminate SARS-CoV-2 from other viruses.

[Proceedings of the National Academy of Sciences of the United States of America] Investigators found that acute Listeria monocytogenes infection produced a phenotypically and functionally complex Treg response comprising two separate suppressor cell subpopulations, with an early Treg peak occurring at 24 hour post-infection and a later peak arising by day seven.

[Cell Reports] The authors identified an interferon-γ-regulated subset of monocytes, CCR2+ monocytes, as a driver of lung damage during influenza A virus infection.

[Nature Cancer] Researchers systematically characterized the interactions between T cells and antigen-presenting myeloid cells within the tumor microenvironment and found that CD4+PD-1+CXCL13+ T cells were a major interacting hub with antigen-presenting cells in the tumor microenvironment of human non-small cell lung carcinoma.