T cells

[Science Immunology] Scientists used multiphoton intravital microscopy in mouse models of hepatitis B to study the intrahepatic behavior of group 1 innate lymphoid cells (ILCs) and their cross-talk with hepatitis B virus–specific CD8+ T cells.

[Scientific Reports] Researchers generated thymus-complemented chimeric mice, assessed the efficacy of anti-PD-L1 antibody in tumor-bearing chimeric mice, and then investigated T cell function.

[International Journal of Biological Macromolecules] The authors discuss the role of TGF-β signaling in proliferation, metastasis and therapy response of prostate cancer cells and in order to improve knowledge towards its regulation, upstream mediators of TGF-β such as non-coding RNAs are described.

[Nature Reviews Immunology] A pivotal event in the history of IL-2 research was solving the crystal structure of IL-2 bound to its tripartite receptor, which spurred the development of cell type-selective engineered IL-2 products.

[Blood Cancer Journal] In CARTITUDE-1, 5% of patients with multiple myeloma reported movement and neurocognitive treatment-emergent adverse events with ciltacabtagene autoleucel (cilta-cel), a B cell maturation antigen-targeted CAR T cell therapy.

[European Respiratory Journal] The total number of cells and the differential cell counts in bronchoalveolar lavage were similar among the study groups.