T cells

[Haematologica] Researchers used sera from 61 immune thrombocytopenia patients and assessed the capacity of antiplatelet antibodies to induce neuraminidase 1 surface expression, RCA-1 lectin binding and loss of mitochondrial inner membrane potential on donors’ platelets.

[Clinical and Translational Medicine] Ten fresh human tissue samples from six patients, including primary tumor and adjacent non-tumoral samples and six metastases from different organs or tissues were evaluated using single-cell RNA sequencing.

[Molecular & Cellular Proteomics] Co-culturing primary CD8+ T cells with Tregs only modestly affected the CD8+ surfaceome but did partially reverse activation-induced surfaceomic changes.

[Nature Reviews Immunology] IL-2 biologics have proven to be effective in preclinical studies and clinical assessment of some is now underway.

[Communications Biology] Researchers used a humanized mouse model to show that while carboplatin plus pembrolizumab reduced tumor growth moderately and transiently, the addition of the tumor suppressor gene TUSC2, delivered systemically in nanovesicles, to this combination, eradicates tumors in the majority of animals.

[Science Advances] Scientists explored the therapeutic potential of targeting PTPN2 in TNBC and T cells. PTPN2-deficiency in TNBC associated with T cell infiltrates and PD-L1 expression, whereas low PTPN2 associated with improved survival.