T cells

[LAVA Therapeutics] LAVA Therapeutics announced dosing of the first patient in the company’s Phase I/IIa clinical trial of LAVA-1207 in patients with metastatic CRPC.

[Clinical Cancer Research] Researchers characterized changes in the soft tissue sarcoma tumor immune microenvironment induced by standard neoadjuvant therapy with the goal of informing neoadjuvant immunotherapy trial design.

[Cell Death & Disease] The authors investigated the impact of apoptotic colorectal cancer cells on neutrophils and its consequence on other immune cells of the tumor microenvironment.

[Journal of Experimental Medicine] The authors investigated the effects of obesity on CD8 T cells in mouse models and patients with endometrial cancer.

[Haematologica] Dendritic cells were either generated from monocytes or isolated directly from blood of healthy donors or graft-versus-host disease patients and co-cultured in a mixed lymphocyte reaction with T cells obtained from healthy donors or transplantation bags.

[Journal of Clinical Investigation] Investigators observed that anti–PD-1 therapy depends on IL-2 signaling, which raised the possibility that a lack of IL-2 limited anti–PD-1–induced effector T cell expansion.