T cells

[EMBO Reports] Investigators showed that loss of DJ-1 encoded by PARK7/DJ-1, causing early-onset familial Parkinson’s disease, unexpectedly diminished signs of immunoaging in T cell compartments of both human and mice.

[Cancer Discovery] Researchers interrogated gene expression and whole-genome CRISPR/Cas9 screening in a large panel of patient-derived glioblastoma (GBM) stem cells (GSCs), differentiated GBM cells, and neural stem cells to identify master regulators of GSC stemness.

[Cancer Research] Investigators quantified tumor infiltration across two distinct clear cell renal cell carcinoma patient tumor cohorts using complementarity determining region-3 (CDR3) sequence recovery counts in tumor-infiltrating lymphocytes and a generalized diversity index for CDR3 sequence distributions.

[Advances in Experimental Medicine and Biology] Researchers measured the levels of inflammation, fibrosis, apoptosis, and necrosis in endomyocardial biopsies and sera of nonischemic PVB19-positive and PVB19-negative dilated cardiomyopathy patients.

[Molecular Therapy-Oncolytics] Investigators constructed a CAR targeting interleukin-13 receptor α2 according to a murine antibody, and then humanized the single-chain variable fragment sequence to generate another CAR.

[Nature Nanotechnology] Researchers demonstrated that subcutaneous delivery via poly(ethylene glycol)-b-poly(propylene sulfide) polymersome nanocarriers significantly altered rapamycin’s cellular biodistribution to repurpose its mechanism of action for tolerance, instead of immunosuppression, and minimize side effects.