Transcription Elongation Machinery Is a Druggable Dependency and Potentiates Immunotherapy in Glioblastoma Stem Cells

Researchers interrogated gene expression and whole-genome CRISPR/Cas9 screening in a large panel of patient-derived glioblastoma (GBM) stem cells (GSCs), differentiated GBM cells, and neural stem cells to identify master regulators of GSC stemness.