Tag results:
T cells
Immune Regulation News
T Cells: Friends and Foes in NASH Pathogenesis and Hepatocarcinogenesis
[Hepatology] Scientists review the specific functions of several T cell populations involved in NAFLD and NAFLD-driven HCC.
Mammary Cell News
Targeting Prooxidant MnSOD Effect Inhibits Triple-Negative Breast Cancer (TNBC) Progression and M2 Macrophage Functions under the Oncogenic Stress
[Cell Death & Disease] Knockdown of MnSOD inhibited TNBC cell invasion, breast cancer stem cells, mitochondrial reactive oxygen species, and interleukin-6 excretion promoted by multiple copies in T cell malignancy-1.
Mammary Cell News
KDM6A Depletion in Breast Epithelial Cells Leads to Reduced Sensitivity to Anticancer Agents and Increased TGF-β Activity
[Molecular Cancer Research] Using MCF10A as a model of non-tumorigenic epithelial breast cells, scientists found that silencing KDM6A promoted cell migration and transformation demonstrated by the formation of tumor-like acini in three-dimensional culture.
Umbilical & Placental Cell News
Comparison of Single and Repeated Dosing of Anti-inflammatory Human Umbilical Cord Mesenchymal Stromal Cells in a Mouse Model of Polymicrobial Sepsis
[Stem Cell Reviews and Reports] Scientists investigated immunomodulatory effects of a novel mesenchymal stem cell product in mouse endotoxemia and polymicrobial sepsis models.
Cell Therapy News
B Cells Imprint Adoptively Transferred CD8+ T Cells with Enhanced Tumor Immunity
[Journal For Immunotherapy of Cancer] Researchers investigated how tumor-specific murine CD8+ T cells and human tumor infiltrating lymphocytes were impacted when expanded ex vivo with the TLR9 agonist CpG.
Immunology of Infectious Disease News
CD4 and CD8 Co-Receptors Modulate Functional Avidity of CD1b-Restricted T Cells
[Nature Communications] Scientists showed CD1b-mycolipid tetramers revealed a hierarchy in which circulating T cells expressing CD4 or CD8 co-receptor stain with a higher tetramer mean fluorescence intensity than CD4-CD8- T cells.