Tag results:
T cells
Cell Therapy News
Comparable Anti-CMV Responses of Transplant Donor and Third-Party CMV-Specific T Cells for Treatment of CMV Infection after Allogeneic Stem Cell Transplantation
[Cellular & Molecular Immunology] The in vivo recovery of cytomegalovirus (CMV)-specific immunity after CMV-cytotoxic T lymphocytes (CTL) infusion was comparable in two groups. A detailed analysis of the source of recovered CMV-CTLs showed the proliferation and expansion of graft-derived endogenous CMV-CTLs in both groups.
Human Immunology News
A GATA4-Regulated Secretory Program Suppresses Tumors through Recruitment of Cytotoxic CD8 T Cells
[Nature Communications] Investigators found that GATA4 promoted non-cell autonomous tumor suppression in multiple model systems. Mechanistically, they showed that Gata4-dependent tumor suppression required cytotoxic CD8 T cells and partially required the secreted chemokine CCL2.
Human Immunology News
Naive T Cell Depletion to Prevent Chronic Graft-Versus-Host Disease
[Journal of Clinical Oncology] 138 patients with acute leukemia received Naive T cell-depleted peripheral blood stem-cell from HLA-matched related or unrelated donors following conditioning with high- or intermediate-dose total-body irradiation and chemotherapy.
Human Immunology News
Human MuStem Cells Repress T Cell Proliferation and Cytotoxicity through Both Paracrine and Contact-Dependent Pathways
[Stem Cell Research & Therapy] The impact of human MuStem cells or their secretome on the proliferative and phenotypic properties of T cells was explored by co-culture experiments with either peripheral blood mononucleated cells or CD3-sorted T cells.
Immunology of Infectious Disease News
Expression of Type I Interferon-Associated Genes at Antiretroviral Therapy Interruption Predicts HIV Virological Rebound
[Scientific Reports] Using RNA-Seq, the authors explored CD4 T cell gene expression to identify evidence of a mechanism that might underpin virological rebound and lead to discovery of associated biomarkers.
Cell Therapy News
D2HGDH-Mediated D2HG Catabolism Enhances the Anti-Tumor Activities of CAR-T Cells in an Immunosuppressive Microenvironment
[Molecular Therapy] In vivo xenograft experiments confirmed D2HGDH-OE CAR-T cell decreased serum D-2-hydroxyglutarate (D2HG) and improved the overall survival of mice bearing NALM6 cancer cells with mutation IDH1.