TIM-3

[Scientific Reports] Researchers studied 76 DAA-treated hepatitis C virus (HCV)-positive patients and 18 non-infected controls. Flow cytometry measured pretreatment frequencies of CD4+PD-1+, CD4+PD-1+Tim-3+ and CD8+PD-1+Tim-3+ T-cells and IL-10 levels measured by ELISA were significantly higher and CD4+PD-1−Tim-3− and CD8+PD-1−Tim-3− T-cells were significantly lower in patients than in controls.

[Nature Communications] Collagen-induced T cell exhaustion occured through the receptor LAIR1, which is upregulated following CD18 interaction with collagen, and induces T cell exhaustion through SHP-1.

[iScience] Investigators found that advanced fibrosis patients had higher frequencies of >3 inhibitory receptor co-expression on NK cells.

[Nature Communications] Investigators report that graft-versus-leukemia failed due to insufficient H60 presentation and T cell exhaustion. Leukemia-derived H60 was inefficiently cross-presented whereas direct T cell recognition of leukemia cells intensifies exhaustion.

[npj Precision Oncology] The authors demonstrated that immune checkpoint molecules could be measured in cervicovaginal lavages. They identified CD40, CD27, and TIM-3 to specifically discriminate cervical cancer from other groups and CD40, CD28, and TLR2 to positively correlate to genital inflammation.