Decrease of T-Cells Exhaustion Markers Programmed Cell Death-1 and T-Cell Immunoglobulin and Mucin Domain-Containing Protein 3 and Plasma IL-10 Levels after Successful Treatment of Chronic Hepatitis C

Researchers studied 76 DAA-treated hepatitis C virus (HCV)-positive patients and 18 non-infected controls. Flow cytometry measured pretreatment frequencies of CD4⁺PD-1⁺, CD4⁺PD-1⁺Tim-3⁺ and CD8⁺PD-1⁺Tim-3⁺ T-cells and IL-10 levels measured by ELISA were significantly higher and CD4⁺PD-1⁻Tim-3⁻ and CD8⁺PD-1−Tim-3⁻ T-cells were significantly lower in patients than in controls.