TLR4

[International Archives of Allergy and Immunology] Cough-variant asthma (CVA) is a special type of asthma, solely manifesting with coughing. Investigators suggested that airway inflammation was associated with CVA pathogenesis.

[Pediatric Research] Scientists demonstrated that melatonin had several significant effects by reducing CD11b and TLR4 expression, attenuating TLR signaling, genes involved in the inflammasome and had the potential to reduce LPS-induced inflammatory responses.

[Journal of Cellular Biochemistry] Coinjections of endothelial progenitor cells + mesenchymal stem cells significantly enhanced the survival rate of lipopolysaccharide-induced mice, decreased concentrations of pro-inflammatory cytokines, and increased the level of anti-inflammatory cytokine.

[Cell Death & Disease] Global lipidomics and RNA sequencing data showed that, in the tumor tissues of colorectal cancer-bearing mouse models, high-fat diet (HFD) not only increased tumor weight, but also the palmitic acid level and TLR4 expression, which were reduced when HFD was replaced by control diet.

[Proceedings of the National Academy of Sciences of the United States of America] In vitro studies demonstrated that IFP35 and NMI were released by multiple cells. IFP35 and NMI subsequently triggered nuclear factor kappa B–dependent activation of microglia via the TLR4 pathway.

[Journal of Immunology] Investigators reported that TLR4 was expressed on granulo-monocytic progenitors, as well as mobilized human peripheral blood CD34+ cells. LPS, a component of Gram-negative bacteria that results in a systemic bacterial infection, induced the differentiation of peripheral blood CD34+ cells into myelocytes and monocytes in vitro via the TLR4 signaling pathway.