Toll-Like Receptor 4 Is a Master Regulator for Colorectal Cancer Growth under High-Fat Diet by Programming Cancer Metabolism

Global lipidomics and RNA sequencing data showed that, in the tumor tissues of colorectal cancer-bearing mouse models, high-fat diet (HFD) not only increased tumor weight, but also the palmitic acid level and TLR4 expression, which were reduced when HFD was replaced by control diet.