TLR4

[Scientific Reports] The authors identified an important caveat when investigating TLR4-driven signaling in BLaER1 cells. They showed that this model contained glycosylphosphatidylinositol anchor-deficient cells, which lacked CD14 surface expression when differentiated to monocytes, resulting in diminished LPS/TLR4 but not TLR7/TLR8 responsiveness.

[Science Translational Medicine] The authors reported the discovery of an intrinsic counter regulatory mechanism in colitis pathogenesis that may be targeted for inflammatory bowel disease treatment.

[Acta Pharmacologica Sinica] The authors investigated the antiviral effects of a Salvia miltiorrhiza compound, Danshensu, in vitro and in vivo, including the mechanism of S protein-mediated virus attachment and entry into target cells.

[Phytotherapy Research] Scientists focused on the regulatory effects of parthenolide, a bioactive component derived from Chrysanthemum parthenium L., against hepatic fibrosis via regulating the crosstalk of toll-like receptor 4 and signal transducer and activator of transcription 3 in activated hepatic stellate cells.

[Scientific Reports] An in-silico approach has been adopted to construct a multi-epitope vaccine from selected immunogenic extracellular vesicle proteins to elicit a cellular as well as a humoral immune response.

[Proceedings of the National Academy of Sciences of the United States of America] Researchers demonstrate that lumican, an ECM protein normally associated with collagens, was elevated in sepsis patients’ blood, while lumican-null mice resolved polymicrobial sepsis poorly, with reduced bacterial clearance and greater body weight loss.