VEGF

[Journal of Medicinal Chemistry] Heme oxygenase-1 (HO-1) promotes heme catabolism exercising cytoprotective roles in normal and cancer cells. Scientists reported the design, synthesis, molecular modeling, and biological evaluation of novel HO-1 inhibitors.

[Cell Reports] By studying physiological homing of fetal hematopoietic stem and progenitor cells (HSPCs), scientists showed the critical requirement of balanced local crosstalk within the skeletal niche for successful HSPC settlement in bone marrow.

[ACS Biomaterials Science & Engineering] Scientists developed a novel angiogenic hydrogel microsphere based on methacrylated hyaluronic acid loaded with VEGF for the treatment of a thin endometrium by a microfluidic electrospray technique.

[Advanced Drug Delivery Reviews] Researchers delve into the mechanisms behind anti-tumor immunity and seeks to identify the differential effect of dosing regimens, including daily low-dose and medium-dose intermittent chemotherapy, on both innate and adaptive immune populations involved in observed anti-tumor immune response.

[npj Regenerative Medicine] Scientists demonstrated that IL-8 was upregulated by the FGF2-mediated priming effect during FECS-Ad formation. Immobilized FGF2 substrate induced stronger IL-8 expression than soluble FGF2 ligands, presumably through the FGFR1/JNK/NF-κB signaling cascade.

[Pediatric Research] Scientists demonstrated that melatonin had several significant effects by reducing CD11b and TLR4 expression, attenuating TLR signaling, genes involved in the inflammasome and had the potential to reduce LPS-induced inflammatory responses.