VEGF

[Nature Communications] Researchers showed that differentiating human iPSC-derived lateral plate mesoderm with BMP4, RA and VEGF could generate a premature form of epicardial cells expressing WT1, TBX18, SEMA3D, and SCX within 7 days.

[Biofabrication] Cardiac spheroids were created from human cardiac myocytes, fibroblasts and endothelial cells, mixed within optimal alginate/gelatin hydrogels and then bioprinted on a microelectrode plate for drug testing.

[Stem Cell Research & Therapy] The authors analyzed hypoxia impact on human and pig bone marrow-derived MSCs and mouse myoblast proliferation, differentiation, and fusion.

[Journal of Bioscience and Bioengineering] Scientists developed a hypoxia-responsive gene expression system for production of an angiogenic factor, vascular endothelial growth factor, to improve hypoxia and nutrition deficiencies inside artificial 3D tissues.

[Scientific Reports] Researchers hypothesized that gastrin might protect against heart injury after myocardial infarction by promoting angiogenesis. Downregulation of HIF-1α expression by siRNA reduced the proliferation, migration and tube formation of human umbilical vein endothelial cells.

[Journal of Cellular and Molecular Medicine] Investigators showed that endogenous stimuli and VEGF were sufficient to induce robust human pluripotent stem cell-derived hematopoiesis, intensive generation of hematopoietic progenitors, maturation of blood cells and the emergence of definitive precursor cells including those that were phenotypically identical to early human embryonic HSCs.