Gastrin Mediates Cardioprotection through Angiogenesis after Myocardial Infarction by Activating the HIF-1α/VEGF Signaling Pathway

Researchers hypothesized that gastrin might protect against heart injury after myocardial infarction by promoting angiogenesis. Downregulation of HIF-1α expression by siRNA reduced the proliferation, migration and tube formation of human umbilical vein endothelial cells.