YAP

[Scientific Reports] Scientists investigated the expression of YAP/TAZ following vocal fold injury in vivo as well as the effects of TGF-β1 on YAP/TAZ activity in human vocal fold fibroblasts, fibroblast-myofibroblast transition, and TGF-β/SMAD signaling.

[Nature Communications] Using cell models from systematic ECM screen to collagen-based 2D and 3D cultures, the authors demonstrated that both specific ECM substrates and stiffness increased resistance to platinum-mediated, apoptosis-inducing DNA damage via FAK and β1 integrin-pMLC-YAP signaling.

[Science Translational Medicine] In mouse models of progressive osseous heteroplasia, a disease caused by null mutations in GNAS, researchers found that Gnas−/− mesenchymal cells secreted Sonic hedgehog (SHH), which induced osteoblast differentiation of the surrounding wild-type cells.

[Experimental & Molecular Medicine] The authors evaluated the expression of estrogen receptor alpha and its association with clinicopathological features in 339 hepatocellular carcinoma patients.

[Hepatology] Researchers demonstrated that the hypoxic microenvironment in primary colorectal cancer lesions boosted exosome release and selectively initiated a favorable pre-metastatic niche formation in the hepar, but not in other organs.

[Oncogene] Reserachers found that high Yes-associated protein (YAP) expression is associated with poor prognosis in malignant glioma patients undergoing radiotherapy.