Zika

[Scientific Reports] Using 3D super resolution microscopy, ZIKV infection was shown to induce the formation of dense tubular matrices associated with viral replication in the central endoplasmic reticulum.

[Science Advances] Scientists report induction of a protective anti-ZIKV CD8+ T cell response in the HLA-B*0702 Ifnar1−/− transgenic mice using an alphavirus-based replicon RNA vaccine expressing ZIKV nonstructural protein NS3, a potent T cell antigen.

[Cell Stem Cell] Investigators showed that the Zika virus-NS5 protein interacts with host proteins at the base of the primary cilia in neural progenitor cells, causing an atypical non-genetic ciliopathy and premature neuron delamination.

[Nature Communications] Scientists investigated how flaviviruses exploit Src family kinases for exit from infected cells. They identifyied Lyn as a critical component for secretion of Dengue and Zika infectious particles and their corresponding virus like particles

[Nature Communications] Investigators used subvolume refinement to achieve a 3.4 Å resolution structure and identify two distinct lipid moieties. The first arose from the inner leaflet and was coordinated by hydrophobic residues of the M and E transmembrane helices that form a binding pocket not previously characterized.

[Nature Communications] Researchers uncovered that NRF2 agonists 4-octyl-itaconate and the clinically approved dimethyl fumarate induced a cellular antiviral program that potently inhibited replication of SARS-CoV2 across cell lines.