adipocytes

[Cell Stem Cell] Scientists uncovered a molecular fate switch, involving miR-206 and the transcription factor Runx1, that controls fibroadipogenic progenitor differentiation to adipocytes.

[PLoS One] The authors characterized the human hematopoietic stem cell and progenitor microenvironment. They obtained three adjacent bone marrow sections from ten healthy volunteers.

[Scientific Reports] The effects of prostaglandin F2α analogues (PGF2α-ags) on human orbital fibroblasts were characterized by lipid staining, comparison of the 3D organoid sizes of preadipocytes or adipocytes that had been treated with various concentrations of several PGF2α-ags, physical stiffness, and the mRNA expression of adipogenic related genes, extracellular matrix, tissue inhibitors of metalloproteinases and matrix metalloproteinases.

[Frontiers in Physiology] The authors review the current knowledge of fibro-adipogenic progenitor function on muscle homeostatic integrity, regeneration, repair, and aging. They also discuss how scar-forming pathologies and disorders lead to dysregulations in their behavior and plasticity and how these stromal cells can control the onset and severity of muscle loss in disease.

[Nature Reviews Clinical Oncology] The authors describe the functional roles of the bone microenvironment and its components in the initiation and propagation of skeletal metastases, outline the biology and clinical relevance of circulating tumor cells and disseminated tumor cells, and discuss established and future therapeutic approaches that specifically target defined components of the bone microenvironment to prevent or treat skeletal metastases.

[Scientific Reports] Using ChIP-Seq against NACA in parallel with RNA-sequencing, investigators report the identification of Ubiquitin Specific Peptidase 53 (Usp53) as a target gene of parathyroid hormone-activated nascent polypeptide associated complex and coregulator alpha in osteoblasts.