airway epithelial cells

[American Journal of Rhinology & Allergy] Investigators attempted to verify angiotensin-converting enzyme 2 (ACE2) expression in the nasal mucosa of patients with seasonal allergic rhinitis induced by Japanese cedar pollen and chronic rhinosinusitis with nasal polyp and to examine the effects of short-chain fatty acids on ACE2 expression in airway epithelial cells.

[Cell Reports] Through in vivo lineage tracing and in vitro molecular experiments, scientists revealed that reduced YAP/TAZ activity promoted intrinsic goblet transdifferentiation of secretory airway epithelial cells.

[Proceedings of the National Academy of Sciences of the United States of America] The authors demonstrated that interdomain communication through small RNA–containing membrane vesicles was bidirectional and that miRNAs in extracellular vesicles secreted by human airway epithelial cells regulated protein expression, antibiotic sensitivity, and biofilm formation by P. aeruginosa.

[Scientific Reports] Researchers hypothesized that the autophagy pathway was required for resolution of mucous metaplasia by eliminating excess non-secreted intracellular mucin granules.

[Clinical Infectious Diseases] Scientists measured the susceptibility to infection, immune response, and expression of adhesion molecules, in human pulmonary microvascular endothelial cells exposed to conditioned medium from infected epithelial cells.

[Nature Microbiology] Investigators showed that the polybasic insertion endows SARS-CoV-2 with a selective advantage in lung cells and primary human airway epithelial cells, but impaired replication in Vero E6, a cell line used for passaging SARS-CoV-2.