alveolar epithelial cells

[Cell Death Discovery] Scientists generated alveolar organoids derived from human pluripotent stem cells for use as an pulmonary fibrosis model and for drug efficacy evaluation.

[American Journal of Physiology-Lung Cellular and Molecular Physiology] In vitro alveolar epithelial cells consistently exhibited a significant induction of reticulocalbin 3 accompanied with NFκB activation in response to LPS exposure.

[Stem Cells] Scientists present an overview and perspectives of the SARS‐CoV‐2 induced inflammatory dysfunction and the potential of MSC immunomodulation for the prevention and treatment of COVID‐19 related pulmonary disease.

[Respiratory Research] The authors found that CXCL16 and its receptor C-X-C motif chemokine receptor 6 (CXCR6) were upregulated in bleomycin induced epithelial–mesenchymal transition in human alveolar type II-like epithelial A549 cells.

[Communications Biology] Investigators present a lung-on-a-chip, based on a biological, stretchable and biodegradable membrane made of collagen and elastin, that emulates an array of tiny alveoli with in vivo-like dimensions.

[Cell Reports] The authors report the activation and repression of innate immune response by SARS-CoV-2. They showed that SARS-CoV-2 RNA activated the RIG-I-MAVS-dependent interferon signaling pathway.