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aplastic anemia

In Vitro Expansion of Fetal Liver Hematopoietic Stem Cells

[Scientific Reports] Scientists explored the expansion of fetal liver hematopoietic stem cells under in vitro conditions. They isolated mononuclear cells from fetal liver and hematopoietic stem cells were identified and analyzed by cell surface marker CD34.

Hematopoietic Stem Progenitor Cells Lacking HLA Differ from Those Lacking GPI-Anchored Proteins in the Hierarchical Stage and Sensitivity to Immune Attack in Patients with...

[Leukemia] To characterize glycosylphosphatidylinositol-anchored protein-deficient and HLA-class I allele-lacking hematopoietic stem progenitor cells in acquired aplastic anemia (AA), researchers studied the peripheral blood of 56 AA patients in remission.

CCR5 Maintains Macrophages in the Bone Marrow and Drives Hematopoietic Failure in a Mouse Model of Severe Aplastic Anemia

[Leukemia] IFNγ was required for increased expression of the chemokine receptor CCR5 on MΦs. CCR5 antagonism in murine SAA improved survival, correlating with increased platelets and significantly increased platelet-biased CD41hi HSCs.

Feasibility of Reduced-Dose Posttransplant Cyclophosphamide and Cotransplantation of Peripheral Blood Stem Cells and Umbilical Cord-Derived Mesenchymal Stem Cells for SAA

[Scientific Reports] Scientists evaluated the effectiveness and safety of reduced-dose cyclophosphamide, 20 mg/kg for 13 patients in matched sibling donor hematopoietic stem cell transplantation (HSCT) cohort and 25 mg/kg for 22 patients in haplo-HSCT cohort, on days +3, +4 combined with cotransplantation of peripheral blood stem cells and human umbilical cord-derived MSCs for severe aplastic anemia (SAA).

Haploidentical Stem Cell Transplantation for Aplastic Anemia: The Current Advances and Future Challenges

[Bone Marrow Transplantation] Scientists provide an overview of clinical results obtained through the use of haploidentical transplantation in severe aplastic anemia, mainly focusing on current advances and future challenges.

A Surge of DNA Damage Links Transcriptional Reprogramming and Hematopoietic Deficit in Fanconi Anemia

[Molecular Cell] Investigators found that reprogramming transcription during hematopoietic differentiation resulted in an overload of genotoxic stress, which caused aborted differentiation and depletion of Fanconi anemia mutant progenitor cells.

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