Hematopoietic Stem Progenitor Cells Lacking HLA Differ from Those Lacking GPI-Anchored Proteins in the Hierarchical Stage and Sensitivity to Immune Attack in Patients with Acquired Aplastic Anemia

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To characterize glycosylphosphatidylinositol-anchored protein-deficient and HLA-class I allele-lacking hematopoietic stem progenitor cells in acquired aplastic anemia (AA), researchers studied the peripheral blood of 56 AA patients in remission.
[Leukemia]
Yoroidaka, T., Hosokawa, K., Imi, T., Mizumaki, H., Katagiri, T., Ishiyama, K., Yamazaki, H., Azuma, F., Nanya, Y., Ogawa, S., & Nakao, S. (2021). Hematopoietic stem progenitor cells lacking HLA differ from those lacking GPI-anchored proteins in the hierarchical stage and sensitivity to immune attack in patients with acquired aplastic anemia. Leukemia, 1–11. https://doi.org/10.1038/s41375-021-01202-8 Cite
Abstract