asthma

[Laboratory Investigation] The authors conducted a study to investigate the effect and mechanisms of action of surfactant protein A in OVA-induced asthmatic mice.

[Journal of Applied Psychology] The authors hypothesized that stiffening of the airway ECM is a core pathological change sufficient to support excessive bronchoconstriction even in the absence of inflammation.

[4D pharma plc] 4D pharma plc announced the completion of its target enrollment of 30 patients for Part A of its Phase I/II clinical trial of MRx-4DP0004 in patients with partly-controlled asthma.

[Experimental and Molecular Medicine] To investigate the effect of OEA, the expression of proinflammatory cytokines was measured by RT-qPCR and ELISA in airway epithelial (A549) cells.

[Connect Biopharma Holdings Limited] Connect Biopharma Holdings Limited announced that the first patient has been dosed in a Phase II trial evaluating CBP-201 in adults with moderate-to-severe persistent asthma.

[Nature Communications] Investigators developed conjugate vaccines against mouse IL-4 and IL-13, and demonstrated their prophylactic and therapeutic efficacy in reducing IgE levels, AHR, eosinophilia and mucus production in mouse models of asthma analyzed up to 15 weeks after initial vaccination.