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Pulmonary Cell NewsInvestigators developed conjugate vaccines against mouse IL-4 and IL-13, and demonstrated their prophylactic and therapeutic efficacy in reducing IgE levels, AHR, eosinophilia and mucus production in mouse models of asthma analyzed up to 15 weeks after initial vaccination.
[Nature Communications]
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Conde, E., Bertrand, R., Balbino, B., Bonnefoy, J., Stackowicz, J., Caillot, N., Colaone, F., Hamdi, S., Houmadi, R., Loste, A., Kamphuis, J. B. J., Huetz, F., Guilleminault, L., Gaudenzio, N., Mougel, A., Hardy, D., Snouwaert, J. N., Koller, B. H., Serra, V., … Reber, L. L. (2021). Dual vaccination against IL-4 and IL-13 protects against chronic allergic asthma in mice. Nature Communications, 12(1), 2574. https://doi.org/10.1038/s41467-021-22834-5 Cite
