asthma

[American Journal of Respiratory Cell and Molecular Biology] Activity of diacylglycerol kinase (DGK) isoforms was inhibited in human airway smooth muscle cells by siRNA-mediated knockdown of DGKα and ζ, while pharmacological inhibition was achieved by pan DGK inhibitor I.

[Experimental & Molecular Medicine] Researchers investigated the mechanism by which S100A9 was involved in neutrophil activation, neutrophil extracellular trap-induced airway inflammation, and macrophage polarization in neutrophilic asthma.

[Journal of Cellular Physiology] The authors investigated the role of prorelaxant cAMP-protein kinase A signaling in diacylglycerol kinase-mediated regulation of airway smooth muscle contraction.

[Scientific Reports] The gene network for the asthmatic and non-asthmatic group was constructed by prioritizing differentially expressed genes and transcription factors. Researchers identified differentially connected or co-expressed genes in each group.

[Scientific Reports]

[Journal of Cellular Physiology] Investigators found that glial cell-derived neurotrophic factor (GDNF) was expressed in human lung and increased in adult asthma, while human airway smooth muscle (ASM) expresses GDNF and its receptors. They used human ASM cells to test the hypothesis that ASM expression and autocrine signaling by GDNF family of ligands regulated [Ca2+]i.