breast cancer cells

[Nature Communications] Scientists demonstrated that obesity-associated tumor formation was driven by cellular adaptation rather than expansion of pre-existing clones within the cancer cell population.

[npj Breast Cancer] The authors characterized a population of stem-like breast cancer cells expressing the integrin αvβ3 as transcriptionally related to activated stem/basal cells in the normal human mammary gland.

[Oncogene] The authors investigated breast cancer cell metabolism reprogramming by circular RNAs (circRNAs) from breast cancer stem cell (BCSC) exosomes and found that BCSC exosome-derived circCARM1 played an important role in breast cancer cell glycolysis by sponging miR-1252-5p which regulated PFKFB2 expression.

[Cancer Gene Therapy] Researchers elucidated the underlying mechanism by which lncRNA UCA1 affected the m6A modification of miR-375 by mediating the DNA methylation of METTL14 and then altering SOX12 expression in breast cancer.

[Cell Death & Differentiation] Researchers uncovered a previously unrecognized mechanistic role for MORC family CW-type zinc finger 2 (MORC2) O-GlcNAcylation in breast cancer progression and provided evidence for targeting MORC2-dependent breast cancer through blocking its O-GlcNAcylation.

[Theranostics] Wnt signaling was activated by the overexpression of Lrp5 and β-catenin in osteoblasts as well as a pharmacological agent and the therapeutic effects of their conditioned medium were evaluated using in vitro cell cultures, ex vivo breast cancer tissues, and a mouse model of osteolysis.