O-GlcNAcylation of MORC2 at Threonine 556 by Ogt Couples TGF-β Signaling to Breast Cancer Progression

Researchers uncovered a previously unrecognized mechanistic role for MORC family CW-type zinc finger 2 (MORC2) O-GlcNAcylation in breast cancer progression and provided evidence for targeting MORC2-dependent breast cancer through blocking its O-GlcNAcylation.