breast cancer

[Molecular Therapy Oncolytics] Investigators loaded umbilical cord-derived MSCs with oncolytic adenoviruses expressing decorin or without foreign genes to treat breast cancer lung metastasis.

[Akeso, Inc. (PR Newswire, Inc.)] Akeso, Inc. announced that Ligufalimab and Ivonescimab have obtained approval from the Center for Drug Evaluation of the National Medical Products Administration of the People's Republic of China to initiate a Phase II clinical trial with chemotherapy as first-line therapy for unresectable locally advanced or metastatic triple negative breast cancer.

[Pharmacological Research] Scientists screened and verified the differential expression of circ_0001142 in breast cancer tissues and cell lines through bioinformatics and qRT-PCR.

[Science Advances] Six candidates among the most commonly shared HLA-A2 epitopes with evidence of translation were selected for immunological evaluation. In vitro priming assays confirmed the immunogenicity of these epitopes, which induced high-avidity CD8+ T cell clones.

[Nature Communications] The authors comprehensively dissected genomic, transcriptomic and clinical data in patient-matched longitudinal tumor samples, and unraveled distinct transcriptional programs enriched in brain metastasis.

[Cell Death & Differentiation] Researchers revealed a novel oncogenic function of IKBKE in promoting breast cancer metastasis by governing Snail abundance, and highlighted the potential of targeting IKBKE for metastatic breast cancer therapies.