breast cancer

[Toxicology and Applied Pharmacology] Investigators observed that proportion of CD133+Nanog+ subpopulation in MCF-7 cells was significantly increased after 3,3′-diindolylmethane administration with up-regulated AKT activity by using CyTOF assay.

[Journal of Natural Medicines] The authors found that camalexin inhibited cell proliferation and migration of breast cancer cell lines. Camalexin also suppressed breast cancer stem cell-derived mammosphere formation.

[Cancer Letters] Scientists designed a meta-analysis to assess gene expression profiles in different breast cancer cell lines focusing on the secretory factors responsible for conversion.

[Cell Death & Differentiation] The authors found that nuclear factor-kB (NF-κB) p65 was a new substrate of the F-box and WD-repeat-containing protein 2 (FBXW2), and that the FBXW2-p65 axis was a crucial regulator of SOX2-induced stemness in breast cancer.

[Nature Communications] To understand the mechanism of this bone-tropism of ER+ tumor, and to identify liquid biopsy biomarkers for patients with high risk of bone metastasis, the secreted extracellular vesicles and cytokines from bone-tropic breast cancer cells were examined.

[British Journal of Cancer] Scientists used a xenograft model of spontaneous metastasis to the liver from an ectopic tumour employing a metastatic TNBC cell line. Atorvastatin was provided to sensitise metastatic cells, followed by chemotherapy.