Ubiquitination of NF-κB p65 by FBXW2 Suppresses Breast Cancer Stemness, Tumorigenesis, and Paclitaxel Resistance

The authors found that nuclear factor-kB (NF-κB) p65 was a new substrate of the F-box and WD-repeat-containing protein 2 (FBXW2), and that the FBXW2-p65 axis was a crucial regulator of SOX2-induced stemness in breast cancer.