cardiomyocytes

[Experimental and Molecular Medicine] Investigators found that CU06-1004, as a vascular leakage blocker, could improve cardiac function by inhibiting cardiac microvascular endothelial cells' hyperpermeability and subsequently reducing the neutrophil’s plugging and infiltration in infarcted hearts.

[Science Advances] By designing RNA-only circuits with miRNA-ON and -OFF switch mRNAs that encoded a lethal ribonuclease, Barnase, and its inhibitor, Barstar, the authors efficiently purified specific cell types, including human iPSCs and differentiated cardiomyocytes, without flow cytometry.

[Nature Review Cardiology] The author summarizes the current evidence on the role of TGFβ signaling in myocardial diseases, focusing on cellular targets and molecular mechanisms, and discussing challenges and opportunities for therapeutic translation.

[Biomaterials] Scientists fabricated aligned human cardiac tissue using a micro-processed fibrin gel with inverted V-shaped ridges and elucidated the effect of alignment control on contractile properties.

[Nature Reviews Cardiology] The authors summarize the current evidence on the role of TGFβ signaling in myocardial diseases, focusing on cellular targets and molecular mechanisms, and discuss challenges and opportunities for therapeutic translation.

[Biomedicine & Pharmacotherapy] The authors provide an overview of the pathways involved with cardiomyocyte in COVID-19 subjects to help promoting pharmacotherapies that can protect against SARS-CoV-2-induced cardiac injuries.