cardiomyocytes

[Scientific Reports] Investigators characterized macrophages in hearts early infused with isoproterenol as compared to control and failing hearts and evaluated the role of upregulated CX3CL1 in cardiac remodeling.

[Acta Pharmacologica Sinica] Scientists investigated the role of lncRNAs in myocardial ischemia-reperfusion injury. Overexpression of p53 canceled the inhibitory effects of lncRNA-6395 knockdown on cardiomyocyte apoptosis, whereas knockdown of p53 counteracted the apoptotic effects of lncRNA-6395 in cardiomyocytes.

[Scientific Reports] The authors demonstrated that entricular tachycardias susceptibility in the chronic phase after myocardial infarction was reduced in mice with cardiomyocyte-specific β-catenin deletion primarily through attenuated structural remodeling, but not ion channel gene alterations.

[Cell Death & Disease] Rat cardiomyocyte cell line H9C2 and primary rat cardiac fibroblasts were cultured in conditioned media generated from epicardial adipose tissue (EAT) of rats in the myocardial infarction 4-week group (EAT-CM). Functionally, EAT-CM enlarged the cell surface area of H9C2 cells and reinforced cardiac fibroblast activation into myofibroblasts by elevating intracellular reactive oxygen species levels.

[Stem Cell Reports] Investigators used a porcine model to provide proof-of-concept evidence that a combination of amiodarone and ivabradine could effectively suppress engraftment arrhythmia.

[Biology Open] The author provides a critical perspective about the main mechanisms contributing to regulate cellular crosstalk in the heart, which may be considered in the development of future therapeutic strategies, using cell-based therapies as a paradigmatic example.