LncRNA-6395 Promotes Myocardial Ischemia-Reperfusion Injury in Mice through Increasing p53 Pathway

Scientists investigated the role of lncRNAs in myocardial ischemia-reperfusion injury. Overexpression of p53 canceled the inhibitory effects of lncRNA-6395 knockdown on cardiomyocyte apoptosis, whereas knockdown of p53 counteracted the apoptotic effects of lncRNA-6395 in cardiomyocytes.