Secretory Products from Epicardial Adipose Tissue Induce Adverse Myocardial Remodeling after Myocardial Infarction by Promoting Reactive Oxygen Species Accumulation

Rat cardiomyocyte cell line H9C2 and primary rat cardiac fibroblasts were cultured in conditioned media generated from epicardial adipose tissue (EAT) of rats in the myocardial infarction 4-week group (EAT-CM). Functionally, EAT-CM enlarged the cell surface area of H9C2 cells and reinforced cardiac fibroblast activation into myofibroblasts by elevating intracellular reactive oxygen species levels.