cardiomyocytes

[Toxicology and Applied Pharmacology] Researchers found that bisphenol A (BPA) exposure altered cardiac function in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). Acute BPA exposure in hiPSC-CMs resulted in reduced field potential, as measured by multielectrode array

[Bioscience Reports] The authors bring together emerging understanding of basement membrane defects within the heart including in common cardiovascular pathologies such as contractile dysfunction and highlight some key questions that are now ready to be addressed.

[Nature Communications] Researchers showed that differentiating human iPSC-derived lateral plate mesoderm with BMP4, RA and VEGF could generate a premature form of epicardial cells expressing WT1, TBX18, SEMA3D, and SCX within 7 days.

[Orizuru Therapeutics, Inc.] Orizuru Therapeutics, Inc. (OZTx) announced the launch of its operations. OZTx is a research and development-driven company focusing on the development of iPSC-based regenerative medicine and the application of iPSC technology.

[Scientific Reports] Scientists screened for targets for the treatment of ischemia–reperfusion injury using a combination of shRNA and drug library analyses in HL-1 mouse cardiomyocytes subjected to hypoxia and reoxygenation.

[Cardiovascular Toxicology] To investigate the role of CAIII in the apoptosis of myocytes under hypoxic conditions and facilitate the strategy for treating hypoxia-induced damage, in vitro experiments in H9c2 were employed.