cardiomyocytes

[Genomics] The authors explored the mechanism of human umbilical cord MSCs-derived extracellular vesicles loaded with miR-223 on myocardial infarction.

[Science Advances] Researchers demonstrated of the use of extracellular vesicles derived from ESCs undergoing cardiac differentiation as biomimetic tools to induce cardiac reprogramming with extremely high efficiency, establishing a general, more readily accessible platform for generating a variety of specialized somatic cells through direct lineage conversion.

[Microsystems & Nanoengineering] The authors discuss recent advances in biosensing platforms for the measurement of contractile functions of in vitro cardiac models, including single cardiomyocytes, 2D monolayers of cardiomyocytes, and 3D cardiac tissues.

[Acta Pharmacologica Sinica] Scientists investigated the protective effect of Dapa against cardiomyopathy caused by high fat diet-induced obesity in vitro and in vivo.

[NPG Asia Materials] Scientists review variations in the myocardial microenvironment and the effects of functional hydrogel systems that are designed to support and mimic this microenvironment during cardiac repair following myocardial infarction.

[Biophysical Journal] Scientists developed a homozygous NaV1.5 KO iPSC line able to differentiate into cardiomyocytes (iPSC-CMs) with CRISPR/Cas9 tool. The NaV1.5 KO iPSC-CMs exhibited an organized contractile apparatus, spontaneous contractile activity, and electrophysiological recordings confirmed the major reduction in total Na+ currents.