Ultraefficient Extracellular Vesicle–Guided Direct Reprogramming of Fibroblasts into Functional Cardiomyocytes

Researchers demonstrated of the use of extracellular vesicles derived from ESCs undergoing cardiac differentiation as biomimetic tools to induce cardiac reprogramming with extremely high efficiency, establishing a general, more readily accessible platform for generating a variety of specialized somatic cells through direct lineage conversion.