caspase-1

[Scientific Reports] Apoptotic cell phagocytosis and soluble TREM2 shedding were unaltered, suggesting a disjoint between the pathways and the signaling cascades downstream of triggering receptor on myeloid cells 2 (TREM2) in R47H-expressing induced pluripotent stem cell-derived microglia (iPS-Mg), whilst metabolic deficits in glycolytic capacity and maximum respiration were reversed when R47H expressing iPS-Mg were exposed to phosphatidylserine+ expressing cells.

[Cell Reports] Scientists summarize recent advances in the understanding of the mechanisms of activation of the NLRP6 inflammasome and discuss its relevance to human disease.

[Nature] Researchers report cryo-electron microscopy structures of the pore and the prepore of gasdermin D.

[Cell Death & Disease] Scientists examined the role of Mint3 in macrophages, which promoted glycolysis via hypoxia-inducible factor-1 activation, during the initiation of pyroptosis following Listeria monocytogenes infection.

[Journal of Biomedical Science] Investigators focus on the role of NLRP3 inflammasome and its components in breast cancer signaling, highlighting that a more detailed understanding of the clinical relevance of these pathways could significantly contribute to the development of novel therapeutic strategies for breast cancer.

[Proceedings of the National Academy of Sciences of the United States of America] Researchers showed that untransformed intestinal epithelial cell layers initiate immediate focal contractions, affecting hundreds to thousands of epithelial cells, in response to bacterial infection.