cell culture

[NPJ Regenerative Medicine] To establish a well-defined 3D cell culture model to mimic the tissue repair process, researchers utilized THP-1 human monocytic cells and a 3D collagen matrix as a biomimetic tissue model.

[Cryobiology] Scientists reported the first comprehensive assessment of cryopreservation of endometrial organoids in the domestic mare.

[Molecular Therapy-Nucleic Acids] The authors provided proof of principle that allele-specific lowering of polyQ-expanded ataxin-3 by selective antisense oligonucleotides was feasible and long lasting with sparing of wildtype ataxin-3 expression in a human cell culture model that was genetically identical to spinocerebellar ataxia type 3 (SCA3) patients.

[Journal For Immunotherapy of Cancer] Autologous tumor organoids were stimulated with T cells from the patients’ peripheral blood for two weeks to generate the organoid-primed T cells.

[Scientific Reports] Researchers investigated if α-tocopherol phosphate, a promising new antioxidant, could protect against long-wave UVA1 induced cell death and scavenge UVA1 induced reactive oxygen species in a skin cell model.

[Cell Death & Disease] The authors found that 3D human placenta-derived MSCs demonstrated a significant increase in secretion of anti-inflammatory factors and trophic factors like VEGF, PDGF, FGF via QPCR and Bio-Plex assays.