cell culture

[Communications Biology] The authors reported the identification of hepatitis C virus NS5A inhibitors Pibrentasvir and Ombitasvir as SARS-CoV-2 exonuclease inhibitors.

[Biophysical Journal] Investigators noted that circulating tumor cells isolated from prostate cancer patients displayed a specific mechanical phenotype, determined with atomic force microscopy: high softness and high adhesion.

[Bone Research] The authors consider both in vitro and in vivo studies that examine the role of Hedgehog in repair and discuss some of the challenges inherent in their interpretation.

[Scientific Reports] Investigators developed a chemically synthetic culture substrate for human PSC attachment and maintenance. The substrate comprised a hydrophobic polyvinyl butyral-based polymer and a short peptide that enabled easy and uniform coating of various types of cell culture ware.

[Journal of Cachexia Sarcopenia and Muscle] Scientists investigated the effect of pancreatic tumour organoid-derived factors on processes that determine skeletal muscle mass, including the regulation of muscle protein turnover and myogenesis.

[Frontiers in Bioengineering and Biotechnology] Researchers discuss applications to address the currently unmet need of developing physiologically relevant in vitro and ex vivo models of ovarian cancer for fundamental discovery science and personalized medicine approaches.